In Vitro Antitumoral Activity of Palladium(II) and Platinum(II) Complexes with O,O'-Dialkyl Esters of Ethylene-bis(S)-Leucine
Jelena M. Vujic, Goran N. Kaluderovic, Tatjana P. Stanojkovic, Jadranka A. Antic and Srecko R. Trifunovic
Affiliation: Institut fur Chemie, Martin- Luther-Univeritat Halle-Wittenberg, Kurt-Mothes-Straße 2, 06120 Halle, Deutschland.
Cytotoxic activity of four O,O'-dialkyl esters of ethylene-bis(S)-leucine [(S,S)-ethylenediamine-N,N’-di-2-(4-
methyl)pentanoic acid] dihydrochlorides, R2edda-type esters L1.2HCl–L4.2HCl (alkyl = Et, n-Pr, n-Bu, and n-Pe, respectively),
and corresponding palladium(II) (1–4) and platinum(II) (5–8) complexes against MDA-MB-361, MDA-MB-453
(human breast cancer), Jurkat (T-leukemia) and K562 (chronic myelogenous leukaemia) cell lines were determined. Results
indicate cytotoxic potential of the investigated complexes based on induction of apoptosis.
Keywords: Palladium(II) complexes, Platinum(II) complexes, EDDA-type ligands, Human breast cancer, T-leukemia, Chronic
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