Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: lddd@benthamscience.org

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Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride

Author(s): Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur. D. Khunt, B. Ramachandra Reddy, Vurimidi Himabindu and Ghanta Mahesh Reddy

Affiliation: Dr.MACS Bio-Pharma (P) Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-85, India.

Keywords: Valacyclovir hydrochloride, Antiviral drug, Improved synthesis, N-Phthalimide-L-Valine ester, Monomethylamine, commercially scalable process, Less cycle time.

Graphical Abstract:


Abstract:

A cost-effective and improved process was developed for the synthesis of the antiviral drug Valacyclovir hydrochloride 1. The process involves the Streglich condensation between 4 and 6 to obtain N-Phthalimide-L-Valine ester 5, which was deprotected by using 40% monomethylamine Overall, the chemistry has been developed and used to prepare Valacyclovir drug 1 in an overall yield of 61 %.

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Article Details

VOLUME: 11
ISSUE: 4
Page: [484 - 487]
Pages: 4
DOI: 10.2174/15701808113106660090