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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 11
ISSUE: 4
DOI: 10.2174/15701808113106660090      Price:  $58









Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride

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Author(s): Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur. D. Khunt, B. Ramachandra Reddy, Vurimidi Himabindu and Ghanta Mahesh Reddy
Pages 484-487 (4)
Abstract:
A cost-effective and improved process was developed for the synthesis of the antiviral drug Valacyclovir hydrochloride 1. The process involves the Streglich condensation between 4 and 6 to obtain N-Phthalimide-L-Valine ester 5, which was deprotected by using 40% monomethylamine Overall, the chemistry has been developed and used to prepare Valacyclovir drug 1 in an overall yield of 61 %.
Keywords:
Valacyclovir hydrochloride, Antiviral drug, Improved synthesis, N-Phthalimide-L-Valine ester, Monomethylamine, commercially scalable process, Less cycle time.
Affiliation:
Dr.MACS Bio-Pharma (P) Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-85, India.