Improved Synthesis of Antiviral Drug Valacyclovir Hydrochloride
Keshava Navin Kumar Reddy, Murugulla Adharvana Chari, Mayur. D. Khunt, B. Ramachandra Reddy, Vurimidi Himabindu and Ghanta Mahesh Reddy
Affiliation: Dr.MACS Bio-Pharma (P) Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-85, India.
Keywords: Valacyclovir hydrochloride, Antiviral drug, Improved synthesis, N-Phthalimide-L-Valine ester, Monomethylamine,
commercially scalable process, Less cycle time.
A cost-effective and improved process was developed for the synthesis of the antiviral drug Valacyclovir hydrochloride
1. The process involves the Streglich condensation between 4 and 6 to obtain N-Phthalimide-L-Valine ester 5,
which was deprotected by using 40% monomethylamine Overall, the chemistry has been developed and used to prepare
Valacyclovir drug 1 in an overall yield of 61 %.
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