Current Chemical Biology

Fernando Albericio  
School of Chemistry
Yachay Tech University
Yachay City of Knowledge, Urcuqui
Ecuador

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Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L.

Author(s): Usama W. Hawas, Lamia T. Abou El-Kassem, Hanem M. Awad and Hanan A.A. Taie

Affiliation: Phytochemistry and Plant Systematic Department, National Research Centre, El-Bohooth Street, 12311, Dokki, Cairo, Egypt.

Keywords: Alzheimer's disease, β-amyloid peptide (Aβ), antioxidant, reducing power, flavonol glycosides, Eryngium campestre.

Abstract:

Phytochemical investigation of the methanolic extract of Eryngium campestre L. aerial parts led to isolation of eleven known flavonol glycosides. Structures were elucidated by spectroscopic and chemical methods. The methanol extract of E. campestre and the isolated flavonols exhibited moderate to strong antioxidant activity in DPPH radical scavenging and reducing power assays. Eryngium campestre extract showed significant inhibition of the ß-amyloid Aß 42 (IC50 = 155.75±7.43 ng/ml) without significant reduction in total Aß (Aß 40 + Aß 42) levels in human H4 cell line, using sensitive sandwich enzyme linked immunosorbent assay (ELISA). The results showed no inhibition activity of the extract against COX-1 and COX-2 up to 400 ng/ml concentration.

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Article Details

VOLUME: 7
ISSUE: 2
Page: [188 - 195]
Pages: 8
DOI: 10.2174/2212796811307020010