Abstract
Synthesis of new chiral thiourea derivatives (27 examples) as anticancer agents has been described. Three compound 7d (NSC code 761448/1), 7e1 (NSC code 767161/1), and 7e3 (NSC code 767160/1) were found to exhibit higher anticancer activity than 5-fluorouracil against Colon cancer, Melanoma, Ovarian cancer, and Breast cancer subpanels. The effect of stereochemistry of amino acid residues on the tumor growth inhibitory activity has also been studied.
Keywords: Amino acid residues, anticancer therapy, thiourea derivatives.
Anti-Cancer Agents in Medicinal Chemistry
Title:Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents
Volume: 14 Issue: 6
Author(s): Vikas Kumar, Akshay Kumar, Vommina V. Sureshbabu and Swapandeep S. Chimni
Affiliation:
Keywords: Amino acid residues, anticancer therapy, thiourea derivatives.
Abstract: Synthesis of new chiral thiourea derivatives (27 examples) as anticancer agents has been described. Three compound 7d (NSC code 761448/1), 7e1 (NSC code 767161/1), and 7e3 (NSC code 767160/1) were found to exhibit higher anticancer activity than 5-fluorouracil against Colon cancer, Melanoma, Ovarian cancer, and Breast cancer subpanels. The effect of stereochemistry of amino acid residues on the tumor growth inhibitory activity has also been studied.
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Cite this article as:
Kumar Vikas, Kumar Akshay, Sureshbabu V. Vommina and Chimni S. Swapandeep, Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2014; 14 (6) . https://dx.doi.org/10.2174/18715206113136660368
DOI https://dx.doi.org/10.2174/18715206113136660368 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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