Synthesis and Stereochemistry-Activity Relationship of Chiral Thiourea Derivatives as Potential Anticancer Agents
Vommina V. Sureshbabu,
Swapandeep S. Chimni.
Synthesis of new chiral thiourea derivatives (27 examples) as anticancer agents has been described. Three compound 7d
(NSC code 761448/1), 7e1 (NSC code 767161/1), and 7e3 (NSC code 767160/1) were found to exhibit higher anticancer activity than
5-fluorouracil against Colon cancer, Melanoma, Ovarian cancer, and Breast cancer subpanels. The effect of stereochemistry of amino
acid residues on the tumor growth inhibitory activity has also been studied.
Keywords: Amino acid residues, anticancer therapy, thiourea derivatives.
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