Abstract
Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs, the calcium and voltage dual dependence,the reorganization of Ca2+-binding site, the mechanisms of direct or indirect activation, the structure-functional relationship, and the possible stereoscopic structure. TMEM16A and other members of the family are associated with several kinds of cancers and other chloride channelopathies. An understanding of TMEM16 associated channel proteins will shed some light on their role in oncology and in pharmacology development.
Keywords: CaCCs, Ca2+-binding site, calmodulin, TMEM16A/B.
Protein & Peptide Letters
Title:TMEM16A/B Associated CaCC: Structural and Functional Insights
Volume: 21 Issue: 1
Author(s): Chunli Pang, Hongbo Yuan, Shuxi Ren, Yafei Chen, Hailong An and Yong Zhan
Affiliation:
Keywords: CaCCs, Ca2+-binding site, calmodulin, TMEM16A/B.
Abstract: Calcium-activated chloride channels (CaCCs) play fundamental roles in numerous physiological processes. Transmembrane proteins 16A and 16B (TMEM16A/B) were identified to be the best molecular identities of CaCCs to date. This makes molecular investigation of CaCCs become possible. This review discusses the latest findings of TMEM16A/B associated CaCCs, the calcium and voltage dual dependence,the reorganization of Ca2+-binding site, the mechanisms of direct or indirect activation, the structure-functional relationship, and the possible stereoscopic structure. TMEM16A and other members of the family are associated with several kinds of cancers and other chloride channelopathies. An understanding of TMEM16 associated channel proteins will shed some light on their role in oncology and in pharmacology development.
Export Options
About this article
Cite this article as:
Pang Chunli, Yuan Hongbo, Ren Shuxi, Chen Yafei, An Hailong and Zhan Yong, TMEM16A/B Associated CaCC: Structural and Functional Insights, Protein & Peptide Letters 2014; 21 (1) . https://dx.doi.org/10.2174/09298665113206660098
DOI https://dx.doi.org/10.2174/09298665113206660098 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Emerging Importance of DNA Helicases to Stabilize the Replication Fork
Current Genomics Role of Acetylcholinesterase Inhibitors in the Metabolism of Amyloid Precursor Protein
Current Drug Targets - CNS & Neurological Disorders Editorial (Thematic Issue: Drug Reprofiling: An Alternative Path to Drug Discovery)
Current Topics in Medicinal Chemistry Role of Cytokines in Chemotherapy-related Cognitive Impairment of Breast Cancer Patients: A Systematic Review
Current Reviews in Clinical and Experimental Pharmacology The Structure and Pharmacological Functions of Coumarins and Their Derivatives
Current Medicinal Chemistry Diet and Neurocognition: Review of Evidence and Methodological Considerations
Current Aging Science Editorial [Hot topic: Targets of Research in the Metabolic Syndrome (Guest Editor: Lindsay Brown)]
Endocrine, Metabolic & Immune Disorders - Drug Targets Carcinogenesis and Therapeutic Strategies in Thyroid Cancer
Current Drug Targets Novel Oral Anticoagulants for Venous Thromboembolism with Special Emphasis on Risk of Hemorrhagic Complications and Reversal Agents
Current Drug Therapy The Akt-mTOR Pathway in Down’s Syndrome: The Potential Use of Rapamycin/Rapalogs for Treating Cognitive Deficits
CNS & Neurological Disorders - Drug Targets CYP2A5 Induction and Hepatocellular Stress: An Adaptive Response to Perturbations of Heme Homeostasis
Current Drug Metabolism Attenuated Oncolytic Measles Virus Strains as Cancer Therapeutics
Current Pharmaceutical Biotechnology Role of Retinoids, Rexinoids and Thyroid Hormone in the Expression of Cytochrome P450 Enzymes
Current Drug Metabolism Immunological and Toxinological Responses to Jellyfish Stings
Inflammation & Allergy - Drug Targets (Discontinued) Preventive Antidepressant use in Patients with Hepatitis C Treated with Interferon-Alfa: a Systematic Review
Current Psychiatry Reviews Calcium Ions in Inherited Cardiomyopathies
Medicinal Chemistry Cucurbitacin E, An Experimental Lead Triterpenoid with Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. A Mini-Review
Current Topics in Medicinal Chemistry Mode of Action of Long-Term Low-Dose Macrolide Therapy for Chronic Sinusitis in the Light of Neutrophil Recruitment
Current Drug Targets - Inflammation & Allergy Molecular Pathways Involved in the Early and Late Damage Induced by Testis Ischemia: Evidence for a Rational Pharmacological Modulation
Current Medicinal Chemistry Type 2 Diabetes Mellitus and Alzheimer’s Disease: Bridging the Pathophysiology and Management
Current Pharmaceutical Design