The gastroretentive drug delivery system is site-specific and allows the drug to remain in the stomach for a
prolonged period of time so that it can be released in a controlled manner in gastrointestinal tract. The present study was
carried out to develop a gastroretentive drug delivery system using isabgol as an excipient to prolong the residence time of
the model drug lisinopril in the stomach. The gastroretentive ability of isabgol was increased by addition of NaHCO3 as a
gas-generating agent while its mucoadhesive property was enhanced by incorporation of HPMC-K4M. The drug, NaHCO3
and HPMC-K3M were imbibed on isabgol-husk as per entrapment efficiency of the isabgol-husk. After drying, the product
was filled in a hard gelatin capsule and evaluated for its buoyancy, mucoadhesive properties, swelling index and in vitro
drug release. The lisinopril released through isabgol was delayed by 12 hours when compared to a preparation available
on the market which released the complete drug in 0.5 hours. The drug release study of lisinopril from the formulation
follows first order kinetics using a diffusion controlled mechanism. The results from the present study revealed that
isabgol can be used as a potential excipient for the formulation of gastroretentive drug delivery systems in the near future.
Keywords: Detachment force, Gastroretentive drug delivery, Lisinopril, Mucoadhesive, Swelling power.
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