Apolipoprotein E Derived Peptides Inhibit the Pro-Inflammatory Effect of Lysophosphatidylcholine

Author(s): Sunil A. Nankar, Jitendra S. Prajapati, Abhay H. Pande.

Journal Name: Protein & Peptide Letters

Volume 21 , Issue 2 , 2014

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Abstract:

Apolipoprotein-derived peptides have emerged as a potential candidate for the treatment of various inflammatory disease conditions. These peptides bind to pro-inflammatory lipids and inhibit their inflammatory functions. Lysophosphatidylcholine (LPC) is a potent pro-inflammatory lipid and increased level of circulating LPC plays a major role in various acute and chronic inflammatory conditions. In this report we examined the effect of peptides derived from the C-terminal domain of human apolipoprotein E on the properties of LPC. Our results show that the peptides (E8, E10 and E11) bind to LPC and inhibit LPC-induced up-regulation of pro-inflammatory markers in human leukocytes. The results suggest that these peptides can be used as an anti-inflammatory agent in inflammatory conditions in which increased level of LPC is a culprit.

Keywords: Apolipoprotein-derived peptide, circular dichroism, fluorescence spectroscopy, inflammation, lysophosphatidylcholine, qRT-PCR.

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Article Details

VOLUME: 21
ISSUE: 2
Year: 2014
Page: [101 - 107]
Pages: 7
DOI: 10.2174/09298665113206660065
Price: $58

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