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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
Epub Full Text Article
DOI: 10.2174/13816128113196660730      Price:  $95









Impact of Antibioticson the Intestinal Microbiota and of Shiga-Toxin-Producing Escherichia Coliand Salmonella Infections Treatment

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Author(s): Jolanta Szych, Tomasz Wołkowicz, Roberto La Ragione and Grzegorz Madajczak
Abstract:
This review evaluates the current literature base on the impact of antibiotics on the intestinal microbiota and the critical role of intestinal bacteria in controlling infection and subsequent clinical disease caused by STEC and Salmonella, and the transmissibility of these important pathogens.A number of studies have indicated that antibiotic therapy could resultin unexpected changes in the clinical picture of disease. This is observed, for example, in the case of infections associated with Shiga-toxin-producing Escherichia coli (STEC), when antibiotics used in treatment of the disease may increase the risk of haemolytic uremic syndrome (HUS) and thus fatal outcomes. In the case of such infections, treatment with antibiotics is usually discouraged. Using of antibiotics could cause also undesirable changes in the intestinal microbial flora and prolonged pathogen shedding, what is observed in the case of Salmonella infections. Inappropriate antibiotic therapy can result in Salmonellaremaining in the host’s cells (intracellular) and thus resulting in further asymptomatic carriage and a further complication is the development of resistance
Keywords:
Escherichia coli, EHEC, STEC, HUS, Salmonella, antibiotics, side effect, microbiota, asymptomatic carriage
Affiliation:
National Institute of Public Health - National Institute of Hygiene, Department of Bacteriology, Chocimska 24, 00-950 Warsaw, Poland