Dystonia Associated with Lamotrigine Therapy: A Case Report and Review of the Literature
Paola C. Marrero-Gonzalez, Orlando L. Ruano, Glenn Catalano and Maria C. Catalano
Affiliation: Mental Health and Behavioral Sciences Service, James A. Haley Veterans Hospital, 13000 Bruce B. Downs, Boulevard #116A, Tampa, Florida 33612.
The association of extrapyramidal side effects (EPS) with the use of conventional antipsychotics is well
established, however, EPS can occur during treatment with anticonvulsant medications as well. We will present the case
of a patient who developed an acute dystonic reaction during treatment with lamotrigine and again during re-challenge
with the same agent. We will review common side effects of this medication and the previous reports of lamotrigineassociated
dystonias. We will also discuss a possible underlying mechanism.
Keywords: Anticonvulsants, dystonia, extrapyramidal symptoms, gamma aminobutyric acid (GABA), lamotrigine, side
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