Incretin Based Therapies: Bone Protective Effects
Marlene Chakhtoura and Sami T. Azar
Affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, American University of Beirut-Medical Center, 3 Dag Hammarskjold Plaza, 8th floor, New York, NY 10017, USA.
Type 2 Diabetes Mellitus (T2D) and osteoporosis have been found recently to be tightly correlated. In fact,
T2D can result in bone loss through different mechanisms resulting in alteration of bone matrix and inhibition of bone
formation. Fracture risk also increases significantly. New antidiabetic agents, dipeptidyl peptidase-4 inhibitors and
glucagon like peptide -1 agonists have shown promise in many fields beyond glycemic control. Benefits on the skeletal
system are multiple through direct stimulation of osteoblasts, inhibition of advanced glycation end products and inhibition
of bone resorption. However, clinical evidence in humans is still not enough to allow definitive conclusions.
Keywords: Dipeptidyl peptidase-4 inhibitors, glucagon like peptide -1 agonists, incretin therapy, osteoporosis, type 2 diabetes
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