Current Organic Synthesis

L.-N. He
Nankai University
Tianjin
P.R. China

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Pyrrolidine-Catalyzed Four-Component One-Pot Synthesis of Dihydropyrano[2,3- C]Pyrazole Derivatives

Author(s): Wang Liju, Keyume Ablajan.

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Abstract:

Pyrrolidine was used as a catalyst for the simple, convenient, and highly efficient synthesis of dihydropyrano[2,3-c]pyrazole derivatives. Four-component one-pot reactions of β-ketoester, hydrazine, ethyl glyoxalate or ethyl pyruvate, and malononitrile in ethanol under reflux conditions led to excellent yields of 79%-94%.

Keywords: Dihydropyrano[2, 3-c]pyrazole, multi-component reactions, one-pot synthesis, Pyrrolidine, Triazolo[4, 3-a]pyrimidines.

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Article Details

VOLUME: 11
ISSUE: 2
Page: [310 - 316]
Pages: 7
DOI: 10.2174/15701794113106660079
Price: $58