An Update on the Chemistry and Medicinal Chemistry of Novel Antimycobacterial Compounds

Author(s): Frederico Silva Castelo Branco, Angelo C. Pinto, Núbia Boechat.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 22 , 2013

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Abstract:

Tuberculosis (TB) is a serious public health issue, particularly in underdeveloped and developing countries. Furthermore the first-line anti-TB treatments were established over 40 years ago, multidrug-resistant Mycobacterium tuberculosis strains have been developed and the risk of coinfection with AIDS virus has highlighted this disease as a global emergency. The urgent need for more effective treatments against multidrug-resistant strains compatible with anti-AIDS drugs has prompted industries, governments and non-governmental agencies to pursue new drugs. In this study, we update the portfolio listed at Stop TB Partnership, present the biological activities as well as structure-activity relationship for these drugs and thoroughly discuss the synthetic methodologies used to produce these drugs.

Keywords: Tuberculosis, chemistry, medicinal chemistry, novel compounds, clinical trial, Mycobacterium tuberculosis.

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Article Details

VOLUME: 13
ISSUE: 22
Year: 2013
Page: [2808 - 2849]
Pages: 42
DOI: 10.2174/15680266113136660201

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