A highly efficient formal inverse electron demand aza Diels–Alder reaction of 1,2-diaza-1,3-dienes (DDs) is accomplished using
dehydroalanine esters (DhAs) as electron-rich dienophiles. Both diastereoisomers of unprecedented ,-disubstituted cyclic tetrahydropyridazine
amino acids were obtained in excellent yields, in refluxing acetonitrile without activation.
Keywords: Cycloaddition reaction, dehydroalanine esters, 1, 2-Diaza-1, 3-dienes, N, N-disubstituted quaternary center, nitrogen heterocycles,
tetrahydropyridazine amino acids.
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