Current Organic Synthesis

Eduardo A. Castro
Universidad Nacional de La Plata
Buenos Aires


A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis.

Author(s): Thavendran Govender, Glenn E.M. Maguire, Hendrik G. Kruger and Morteza Shiri

Affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.

Keywords: Cyanoacetyl indoles (CAIs), Friedel-Crafts, cyclisation, heterocycles, indoles, pyridines, quinolines.


Cyanoacetylindoles (CAIs) are easily obtained from the reaction of indoles and cyanoacetic acid, and are used as versatile starting materials in the synthesis of different heterocycles. This review focuses on the application of CAIs to generate a large diversity of indolyl heterocycles such as pyrazoles, triazoles, pyridines, dihydropyridines, pyrimidines, ozathiols, thiophenes, oxazoles, quinolines and many other complex heterocycles.

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Article Details

Page: [737 - 750]
Pages: 14
DOI: 10.2174/1570179411310050005