A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis.
Thavendran Govender, Glenn E.M. Maguire, Hendrik G. Kruger and Morteza Shiri
Affiliation: Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.
Cyanoacetylindoles (CAIs) are easily obtained from the reaction of indoles and cyanoacetic acid, and are used as versatile
starting materials in the synthesis of different heterocycles. This review focuses on the application of CAIs to generate a large diversity of
indolyl heterocycles such as pyrazoles, triazoles, pyridines, dihydropyridines, pyrimidines, ozathiols, thiophenes, oxazoles, quinolines
and many other complex heterocycles.
Keywords: Cyanoacetyl indoles (CAIs), Friedel-Crafts, cyclisation, heterocycles, indoles, pyridines, quinolines.
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