A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis.
Glenn E.M. Maguire,
Hendrik G. Kruger,
Cyanoacetylindoles (CAIs) are easily obtained from the reaction of indoles and cyanoacetic acid, and are used as versatile
starting materials in the synthesis of different heterocycles. This review focuses on the application of CAIs to generate a large diversity of
indolyl heterocycles such as pyrazoles, triazoles, pyridines, dihydropyridines, pyrimidines, ozathiols, thiophenes, oxazoles, quinolines
and many other complex heterocycles.
Keywords: Cyanoacetyl indoles (CAIs), Friedel-Crafts, cyclisation, heterocycles, indoles, pyridines, quinolines.
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