Alkylboronate Synthesis Based on Transition Metal-Catalyzed Hydroboration.
Saipeng Huang, Yuanchao Xie, Shaolei Wu, Meirong Jia, Junhua Wang, Wenfeng Xu and Hao Fang
Affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong. 250012, China.
Alkylboronate derivatives are important intermediates in organic synthesis and medicinal chemistry. The research of synthesizing
alkylboronic acid derivatives has attracted great attention of chemists and many papers have reported various methods for preparing
alkylboronates based on transition-metal-catalyzed hydroboration. In this review, we summarize the methods of synthesizing alkylboronate
derivatives with different catalysts, such as Rhodium, Palladium, Copper, Iridium, Iron, Magnesiu, Platinum, Nickel and so on.
Pinacolborane, bispinacolatodiboron and catecholborane are applied as important reagents and substrates with different skeleton structures
and functional groups are employed to prepare diversity of alkylboronates.
Keywords: Alkylboronate, alkylboronic derivatives, catalyst, hydroboration, transition metal.
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