Emerging Electrical Biosensors for Detecting Pathogens and Antimicrobial Susceptibility Tests
Pei-Wen Yen, Yen-Pei Lu, Chih-Ting Lin, Chi-Hung Hwang, J. Andrew Yeh, Ming-Yu Lin and Keng-Shiang Huang
Affiliation: Instrument Technology Research Center, National Applied Research Laboratories, 20, R & D Road VI, Hsinchu, 30076, Taiwan.
The past decade has witnessed the development of innovative biosensing technologies for detecting pathogens, and evaluating
the anti-microbial susceptibility test in the infectious diseases. Recent advances in the field have been focused on the development of
miniaturized biosensors with high sensitivity, specificity and stability. Possibility for commercialization is also a key criterion to develop
biosensors in reality. In this article, we introduced several electrical-based biosensors with prospective for commercialization. To have an
in-field detection for pathogens, the electrical biosensor is promising because of its ease to be implemented with micro/nano fabrication
technologies. Several electrical biosensing techniques, such as ion-sensitive field effect transistor, nanowire, and microcantilever have
been introduced. In addition, advantages and achievements of each electrical biosensing technique have also been reviewed.
Keywords: Pathogens, Electrical biosensors, Human immunodeficiency virus (HIV), Tuberculosis (TB), group B Streptococcus (GBS),
methicillin-resistant Staphylococcus aureus (MRSA).
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