Vesicles: A Recently Developed Novel Carrier for Enhanced Topical Drug Delivery
Affiliation: School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Moradabad-244001, Uttar Pradesh, India.
As skin is one of the crucial and important organs of the human body, delivering the drug across it requires an
effective development in the field of research. Topical drug delivery system is specifically designed with the objective to
accomplish the delivery of therapeutically active drugs across the skin. Though skin is considered to be a multifunctional
organ of a human body, it has the limitation of lesser permeability across the stratum corneum. As this layer constitutes an
effective barrier for the drugs, various carrier systems have been developed to overcome this barrier. Vesicular carriers are
one of the recently invented carriers. Liposomes, niosomes, transferosomes and ethosomes constitute the major part of
these vesicles that have been sufficiently employed for the treatment of variety of topical skin diseases. In the past few
years various research reports on the development of topical carrier systems showed that these carriers have emerged as a
novel vesicular carrier. These are considered to be effective enough for the enhanced and safe delivery of both hydrophilic
and lipophilic drugs. The present review focuses on the topical delivery via these vesicles, emphasizing on various aspects
of all these carriers.
Keywords: Drug, enhanced, permeation, skin, topical, vesicles.
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