Semicarbazone Analogs as Anticonvulsant Agents: A Review
Mohamed Jawed Ahsan
Affiliation: Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan 302 023, India.
Keywords: Anticonvulsant Agents, Binding site theory, Na+ channel blocker, Pharmacophore model, Review, Semicarbazones.
Semicarbazones are synthesized by the condensation of semicarbazide and aldehyde/ketone. The literature
survey revealed that semicarbazones had been emerged as compounds with diverse biological activities including
anticonvulsant, antitubercular, anticancer, and antimicrobial activities. The anticonvulsant activity of semicarbazones is
mainly attributed due to the presence of an aryl binding site with aryl/alkyl hydrophobic group, a hydrogen bonding
domain and an electron donor group and they are suggested to act by inhibiting sodium ion (Na+) channel. Dimmock et
al., reported an extensive series of semicarbazones and reported 4-(4-fluorophenoxy) benzaldehyde semicarbazone
(C0102862, V102862) as lead molecule. In MES (oral) screening C0102862 showed protective index (PI > 315) more
than carbamazepine (PI 101), phenytoin (PI > 21.6) and valproate (PI > 2.17). This review briefly describes the
information available about semicarbazone analogs and their anticonvulsant activity.
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