Chlamydia trachomatis is the most common sexually transmitted bacterial infection worldwide. The
impact of this pathogen on human reproduction has intensified research efforts to better understand chlamydial
infection and pathogenesis. Whilst there are animal models available that mimic many aspects of human
chlamydial infection, the mouse is regarded as the most practical and widely used of the models. Studies in
mice have greatly contributed to our understanding of the host-pathogen interaction and provided an excellent
medium for evaluating vaccines. Here we explore the advantages and disadvantages of all animal models of
chlamydial genital tract infection, with a focus on the murine model and what we have learnt from it so far.
Keywords: Animal model, adjuvant, Chlamydia, Chlamydia muridarum, immunization, infertility, vaccine.
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