Biomarkers of Alzheimer’s Disease: An Overview of the Recent Inventions
Obulesu Magisetty, Jhansilakshmi Magisetty, Dhanalakshmi Magisetty and Lakshmi Magisetty
Affiliation: Department of Materials Science, Graduate School of Pure and Applied Sciences, Tsukuba University, Tsukuba, Ibaraki 305-8573, Japan.
The etiology of Alzheimer’s disease (AD) is complex which includes oxidative stress, apoptosis, mutations in
genes, imbalance in metal homeostasis and neuroinflammation. Biomarkers such as micro RNAs, peptides, protein
complexes and genes in various body fluids of AD patients play a pivotal role not only in diagnosis of the disease but also
in following the therapeutic effects of drugs employed to treat this neurodegenerative disorder. However, there has been a
substantial dearth in diagnosing this disease at the earliest. This review focuses on recent advances and patents in the field
of biomarkers of AD. It strongly emphasizes the growing need to translate the available and upcoming knowledge into
substantial clinical trials to streamline a vital armamentarium for the disease.
Keywords: Alzheimer’s disease, biochips, biomarker, genes, miRNA, protein complex
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