Letters in Drug Design & Discovery

Atta-ur-Rahman  , FRS
Honorary Life Fellow
Kings College
University of Cambridge
Email: lddd@benthamscience.org


Synthesis of Sulfur Containing Colchicine Derivatives and their Biological Evaluation as Cytotoxic Agents

Author(s): Joanna Kurek, Wladyslaw Boczon, Krzysztof Myszkowski, Marek Murias, Teresa Borowiak and Irena Wolska

Affiliation: Laboratory for Chemistry of Heterocyclic Compounds, Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland.


Semi-synthetic C-10 alkyl thio analogues of the cytotoxic natural alkaloid colchicine have been found to exhibit cytotoxicity towards tumour cell lines at levels comparable to that of the natural product. An efficient synthesis of 10-alkyl thiocolchicines in mild conditions is proposed and the products are studied by 1H and 13C NMR, FT-IR, MS-EI methods and elementary analysis. The crystal structure of 10-ethylthiocolchicine is characterised using X-ray diffraction methods. Cytotoxic activity against selected cancer cell lines for all obtained 10-alkylthio analogues of colchicine is also reported.

Keywords: 10-alkylthiolcolchicine derivatives, Spectral characterisation, Cytotoxic activity, Crystal structure of 10-ethylthiocolchicine.

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Article Details

Page: [279 - 289]
Pages: 11
DOI: 10.2174/15701808113106660086