Synthesis of Sulfur Containing Colchicine Derivatives and their Biological Evaluation as Cytotoxic Agents
Joanna Kurek, Wladyslaw Boczon, Krzysztof Myszkowski, Marek Murias, Teresa Borowiak and Irena Wolska
Affiliation: Laboratory for Chemistry of Heterocyclic Compounds, Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, Poland.
Keywords: 10-alkylthiolcolchicine derivatives, Spectral characterisation, Cytotoxic activity, Crystal structure of 10-ethylthiocolchicine.
Semi-synthetic C-10 alkyl thio analogues of the cytotoxic natural alkaloid colchicine have been found to exhibit
cytotoxicity towards tumour cell lines at levels comparable to that of the natural product. An efficient synthesis of
10-alkyl thiocolchicines in mild conditions is proposed and the products are studied by 1H and 13C NMR, FT-IR, MS-EI
methods and elementary analysis. The crystal structure of 10-ethylthiocolchicine is characterised using X-ray diffraction
methods. Cytotoxic activity against selected cancer cell lines for all obtained 10-alkylthio analogues of colchicine is also
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