The stereoselective synthesis of an antifungal drug, Terbinafine, bearing (E)-tert-butylenyne structural element
as the side chain is achieved by coupling N-methyl-1-napthalene methanamine with 1-bromo-6,6-dimethyl-2E-hepten-4-
yne in good yield. The new methodology avoids the use of toxic starting materials like acrolein and phosphorous pentachloride
that were used in earlier reports. The structure was confirmed by IR, NMR, MS, and elemental analysis.
Keywords: Terbinafine, alkylation, stereoselective synthesis, selective reduction, antifungal drug.
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