Drug Delivery Letters

Marc Schneider  
Biopharmaceutics and Pharmaceutical Technology
Department of Pharmacy
Saarland University
661213 Saarbrücken


Review on Novel Carrier System: Liposomes and Proliposomes

Author(s): Gangadhar Veerapu, H.V. Gangadharappa, B. Nagashubha and V. Balamuralidhara

Affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, S.S Nagar, Mysore-570015, India.


For many years, improvements have been made in certain attempts for liposomal stability, by several methods, including preparing more stable bi-layers, coating their surface with protecting polymers, and modifying charge. These methods on subjecting to certain changes have led to a novel type of liposomes called proliposomes. Dry, free-flowing particles with a dispersed system that can form a liposomal suspension immediately when in contact with water called Proliposomes. These Proliposomes are as good as or even better than conventional liposomes. Because of their solid properties, the physical stability of liposomes can also be improved upon without influencing their intrinsic characteristics and show more advantages in promoting drug absorption. Therefore, proliposomes would be a potential vehicle to help improve the oral absorption of hydrophobic drugs. The focus of this review is to bring out different aspects related to liposomes, Proliposomes preparation, characterization, entrapment efficiency, in vitro drug release, applications and merits.

Keywords: Cholesterol, liposome, phospholipid, proliposome, reticulo endothelial system (RES).

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [96 - 109]
Pages: 14
DOI: 10.2174/22103031113036660019