Review on Novel Carrier System: Liposomes and Proliposomes
Gangadhar Veerapu, H.V. Gangadharappa, B. Nagashubha and V. Balamuralidhara
Affiliation: Department of Pharmaceutics, JSS College of Pharmacy, JSS University, S.S Nagar, Mysore-570015, India.
For many years, improvements have been made in certain attempts for liposomal stability, by several methods,
including preparing more stable bi-layers, coating their surface with protecting polymers, and modifying charge. These
methods on subjecting to certain changes have led to a novel type of liposomes called proliposomes. Dry, free-flowing
particles with a dispersed system that can form a liposomal suspension immediately when in contact with water called
Proliposomes. These Proliposomes are as good as or even better than conventional liposomes. Because of their solid properties,
the physical stability of liposomes can also be improved upon without influencing their intrinsic characteristics and
show more advantages in promoting drug absorption. Therefore, proliposomes would be a potential vehicle to help improve
the oral absorption of hydrophobic drugs. The focus of this review is to bring out different aspects related to liposomes,
Proliposomes preparation, characterization, entrapment efficiency, in vitro drug release, applications and merits.
Keywords: Cholesterol, liposome, phospholipid, proliposome, reticulo endothelial system (RES).
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