Synthesis and Antibacterial Activity of 4,5-disubstituted-1,2,4-triazole-3- thiones

Title:Synthesis and Antibacterial Activity of 4,5-disubstituted-1,2,4-triazole-3- thiones

Volume: 10 Issue: 10

Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska and Anna Malm

Affiliation:

Keywords: 3-chlorobenzhydrazide, MIC, MBC, Opportunistic bacteria.

Abstract: Sixteen derivatives of 1,2,4-triazole-3-thione were obtained starting from 3-chlorobenzoic acid hydrazide. Structures of the investigated compounds were confirmed by ¹H NMR, IR and elemental analyses. 4-(2,4- Dichlorophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione exhibited the highest antibacterial activity, which exceeded the activity of commonly used antibiotics (ampicillin, cefuroxime) against Bacillus cereus ATCC10876. The obtained results allowed verification of the previously formulated hypothesis of a correlation between the molecules’ dipole moment values and their antibacterial activity.

Cite this article as:

Plech Tomasz, Wujec Monika, Kosikowska Urszula and Malm Anna, Synthesis and Antibacterial Activity of 4,5-disubstituted-1,2,4-triazole-3- thiones, Letters in Drug Design & Discovery 2013; 10 (10) . https://dx.doi.org/10.2174/15701808113109990082