Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis and Antibacterial Activity of 4,5-disubstituted-1,2,4-triazole-3- thiones

Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska, Anna Malm.

Abstract:

Sixteen derivatives of 1,2,4-triazole-3-thione were obtained starting from 3-chlorobenzoic acid hydrazide. Structures of the investigated compounds were confirmed by 1H NMR, IR and elemental analyses. 4-(2,4- Dichlorophenyl)-5-(3-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione exhibited the highest antibacterial activity, which exceeded the activity of commonly used antibiotics (ampicillin, cefuroxime) against Bacillus cereus ATCC10876. The obtained results allowed verification of the previously formulated hypothesis of a correlation between the molecules’ dipole moment values and their antibacterial activity.

Keywords: 3-chlorobenzhydrazide, MIC, MBC, Opportunistic bacteria.

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Article Details

VOLUME: 10
ISSUE: 10
Year: 2013
Page: [917 - 922]
Pages: 6
DOI: 10.2174/15701808113109990082
Price: $58