Synthesis and Antibacterial Activity of Novel Chalcone Derivatives of Apocynin
P. Acharya Nagarjuna,
N. J. P. Subhashini.
A series of novel chalcones 1a- 1l (12 compounds) has been synthesized by using commercially available apocynin
and aromatic aldehydes. The newly synthesized chalcone derivatives were screened for their antibacterial activities
against gram positive and gram negative bacteria at the concentrations 10 of μg/mL with reference to the standard antibacterial
drug Gentamycin. The screening results revealed that among the tested analogs, compounds having the hetero rings
such as benzo[b]furan, furan and pyridine (1j,1k and 1l) in the structure exhibited excellent antibacterial activity while
the compounds bearing fluorine, 2-CF3, 4-CF3 and 4-OCF3 (1f, 1g, 1h and 1i) also exhibited good to excellent activity.
Keywords: Chalcones, Apocynin, Aldehydes, Synthesis, Gram positive, antibacterial activity.
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