Assessment of Hupu Gum for Its Carrier Property in the Design and Evaluation of Solid Mixtures of Poorly Water Soluble Drug - Rofecoxib
Harini Chowdary Vadlamudi, Y. Prasanna Raju, G. Asuntha, Rahul Nair, K.V. Ramana Murthy and Jayasri Vulava
Affiliation: Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A.Rangampet, Tirupati, 517102, Andhra Pradesh, India.
There are no reports about the pharmaceutical applications of hupu gum (HG). Hence the present study was
undertaken to test its suitability in the dissolution enhancement of poorly water soluble drug. Rofecoxib (RFB) was taken
as model drug. For comparison solid mixtures were prepared with carriers such as poly vinyl pyrrolidone (PVP), sodium
starch glycollate (SSG) and guar gum (GG). Physical mixing (PM), co-grinding (CG), kneading (KT) and solvent evaporation
(SE) techniques were used to prepare the solid mixtures, using all the carriers in different carrier and drug ratios.
The solid mixtures were characterized by powder X-ray diffraction (XRD) and Fourier-transformed infrared spectroscopy
(FTIR). There was a significant improvement in the dissolution rate of solid mixtures of HG, when compared with the
solid mixtures of other carriers. There was an increase in dissolution rate with increase in concentration of HG upto 1:1 ratio
of carrier and drug. No drug-carrier interaction was found by FTIR studies. XRD studies indicated reduction in crystallinity
of the drug with increase in HG concentration. Hence HG could be a useful carrier for the dissolution enhancement
of poorly water soluble drugs.
Keywords: Carriers, Dissolution parameters, Dissolution rate, Drug release kinetics, Hupu gum, Rofecoxib, Solubility.
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