Medicinal Chemistry

Atta-ur-Rahman  
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK
Email: mc@benthamscience.org

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Chemistry, Stability and Bioavailability of Resveratrol

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Abstract:

Resveratrol is a bioactive polyphenol found in many vegetables. It is well known for its multiple pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, anticancer, neuroprotective and cardioprotective effects. In vitro evidence of resveratrol efficacy is widespread, however, many concerns regarding its effectiveness in vivo arise from its poor stability in vitro and bioavailability following oral ingestion. This review focuses on the in vitro stability, with special focus on the photochemical stability of resveratrol, and on the therapeutic perspectives of this molecule due to its low bioavailability.

Keywords: Bioavailability, isomerisation, oxidation, phenantrenic derivatives, photochemical reactions, resveratrol.

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2014
Page: [237 - 245]
Pages: 9
DOI: 10.2174/15734064113096660053
Price: $58