Synthesis of an Estradiol Derivative with an Adenosine-phosphate Mimic Linked at Position 16β

Author(s): Amelie Talbot, Rene Maltais, Donald Poirier.

Journal Name: Current Organic Synthesis

Volume 11 , Issue 4 , 2014

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Graphical Abstract:


We describe the synthesis and characterization of three compounds targeting the enzyme 17β-hydroxysteroid dehydrogenase type 1. The first one is a 4-aminobenzoyl-phenylacetic acid derivative designed as a mimic of adenosine-phosphate, the second one is an estradiol derivative having a decyl side chain at position 16β, and the third one is a hybrid compound with the adenosine-phosphate mimic covalently linked to the C16-estradiol side chain. Judicious use of key reactions such as Claisen rearrangement, microwave Grignard alkylation, selective TEMPO oxidation and cross metathesis has been required to achieve these targeted molecules.

Keywords: Cofactor mimics, cross-metathesis reaction, enzyme substrate, estradiol derivative, hybrid inhibitor, steroid.

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Article Details

Year: 2014
Page: [612 - 620]
Pages: 9
DOI: 10.2174/15701794113106660078
Price: $58

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