Abstract
Several studies have attempted to clarify molecular pathways leading to drug addiction. Increased reactive oxygen species production in the central nervous system has been recently proposed to play a pivotal role in the neuropathology induced by drug abuse. In this review, we summarize current knowledge on the involvement of oxidative stress in the development of neural dysfunctions induced by prolonged exposure to specific drugs of abuse: N-methyl-D-aspartate receptor antagonists (ketamine, phencyclidine and dizocilpine maleate), cocaine, heroin, marijuana, gammahydroxybutyrate, amphetamine and methamphetamine. Understanding the role of increased oxidative damage in the central nervous system following abuse of these compounds may provide original molecular perspectives leading to innovative therapeutic strategies.
Keywords: Amphetamine, central nervous system, cocaine, GHB, heroin, marijuana, NMDA-antagonists, oxidative stress.
Mini-Reviews in Organic Chemistry
Title:Drugs of Abuse and Oxidative Stress in the Brain: From Animal Models to Human Evidence
Volume: 10 Issue: 4
Author(s): Stefania Schiavone, Marilena Colaianna and Luigia Trabace
Affiliation:
Keywords: Amphetamine, central nervous system, cocaine, GHB, heroin, marijuana, NMDA-antagonists, oxidative stress.
Abstract: Several studies have attempted to clarify molecular pathways leading to drug addiction. Increased reactive oxygen species production in the central nervous system has been recently proposed to play a pivotal role in the neuropathology induced by drug abuse. In this review, we summarize current knowledge on the involvement of oxidative stress in the development of neural dysfunctions induced by prolonged exposure to specific drugs of abuse: N-methyl-D-aspartate receptor antagonists (ketamine, phencyclidine and dizocilpine maleate), cocaine, heroin, marijuana, gammahydroxybutyrate, amphetamine and methamphetamine. Understanding the role of increased oxidative damage in the central nervous system following abuse of these compounds may provide original molecular perspectives leading to innovative therapeutic strategies.
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Schiavone Stefania, Colaianna Marilena and Trabace Luigia, Drugs of Abuse and Oxidative Stress in the Brain: From Animal Models to Human Evidence, Mini-Reviews in Organic Chemistry 2013; 10 (4) . https://dx.doi.org/10.2174/1570193X113106660030
DOI https://dx.doi.org/10.2174/1570193X113106660030 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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