Mini-Reviews in Organic Chemistry

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Drugs of Abuse and Oxidative Stress in the Brain: From Animal Models to Human Evidence

Author(s): Stefania Schiavone, Marilena Colaianna and Luigia Trabace

Affiliation: Department of Mental Health and Psychiatry, Geneva University Hospital, and University of Geneva, CH- 1225 Chêne Bourg (GE), Geneva, Switzerland.

Keywords: Amphetamine, central nervous system, cocaine, GHB, heroin, marijuana, NMDA-antagonists, oxidative stress.

Abstract:

Several studies have attempted to clarify molecular pathways leading to drug addiction. Increased reactive oxygen species production in the central nervous system has been recently proposed to play a pivotal role in the neuropathology induced by drug abuse. In this review, we summarize current knowledge on the involvement of oxidative stress in the development of neural dysfunctions induced by prolonged exposure to specific drugs of abuse: N-methyl-D-aspartate receptor antagonists (ketamine, phencyclidine and dizocilpine maleate), cocaine, heroin, marijuana, gammahydroxybutyrate, amphetamine and methamphetamine. Understanding the role of increased oxidative damage in the central nervous system following abuse of these compounds may provide original molecular perspectives leading to innovative therapeutic strategies.

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Article Details

VOLUME: 10
ISSUE: 4
Page: [335 - 342]
Pages: 8
DOI: 10.2174/1570193X113106660030