Mini-Reviews in Organic Chemistry


Tuning the Activity of Antioxidants from a Chemical Point of View

Author(s): Waled Tantawy

Affiliation: Photochemistry Department, National Research Center, Dokki, Giza, Egypt.

Keywords: 2c-3e interaction, antioxidant activity, GPx activity, -stacking, PCET, pro-oxidant activity, selenocompounds.


The current work discussed the criteria that control the non-enzymatic and enzymatic antioxidant activity from a chemical point of view. Two tunable strategies were classified to emphasize the reactivity of non-enzymatic one from the thermodynamic and kinetic perspectives. On the other hand, the non-covalent interactions and the intermediacy of reactive compounds formation were found to be the most efficient tools to modulate the activity of enzymatic antioxidant. Furthermore, the light has been shed on the pro-oxidant behavior of some antioxidants.

Order Reprints Order Eprints Rights & PermissionsPrintExport

Article Details

Page: [186 - 224]
Pages: 39
DOI: 10.2174/1570193X113106660021