Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities
Mosaad S. Mohamed and Samar S. Fathallah
Affiliation: Helwan University, Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, Ein-Helwan, Cairo, Egypt.
For several decades, interest in pyrrole derivatives increased due to their pharmaceutical importance, such as
antimicrobial, anti-inflammatory, analgesic, anti-tumor, anti-epileptic, anti-viral, anti-hypertensive, and anti-diabetic
agents. These huge therapeutic applications have motivated new efforts in searching for novel derivatives with improved
biological activity and diverse applications in pharmaceutical industry. Motivated by the importance of this system, and in
continuation of our research efforts, we have tried to highlight aspects reported on the chemistry and biological activity of
pyrrole and its fused derivatives during the past years (till 2012).
Keywords: Pyrrole, fused pyrrole, pyrrolopyrimidine, synthesis, biological activities and drugs.
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