Recent Advances in the Use of Cyclodextrins in Antifungal Formulations

Author(s): Fliur Macaev, Veaceslav Boldescu, Athina Geronikaki, Natalia Sucman.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 21 , 2013

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Abstract:

Cyclodextrins are usually used in antifungal formulations as auxiliary substances to improve solubility, stability, or other physicochemical properties of the active compound. Nevertheless, more and more research and practical use results indicate that cyclodextrins might also act as active compounds in pharmaceutical formulations. The biological effects of cyclodextrins, important for their use within antimycotic formulations, can be divided into: effects based on the ability of cyclodextrins to form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), effects based on formation of inclusion complexes with component parts of fungi cells, and effects based on the chemical nature of cyclodextrins and their derivatives. This review will cover the advances in research of biological activity of cyclodextrins with focus on their properties responsible for their synergistic effect with antimycotic compounds.

Keywords: Antimycotic, cyclodextrins, synergistic effect.

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Article Details

VOLUME: 13
ISSUE: 21
Year: 2013
Page: [2677 - 2683]
Pages: 7
DOI: 10.2174/15680266113136660194
Price: $58

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