Abstract
The present review reports the antifungal activity of mushroom extracts and isolated compounds including high (e.g. peptides and proteins) and low (e.g. sesquiterpenes and other terpenes, steroids, organic acids, acylcyclopentenediones and quinolines) molecular weight compounds. Most of the studies available on literature focused on screening of antifungal activity of mushroom extracts, rather than of isolated compounds. Data indicate that mushroom extracts are mainly tested against different Candida species, while mushroom compounds are mostly tested upon other fungi. Therefore, the potential of these compounds might be more useful in food industry than in clinics. Oudemansiella canarii and Agaricus bisporus methanolic extracts proved to be the most active mushroom extracts against Candida spp. Grifolin, isolated from Albatrellus dispansus, seemed to be the most active compound against phytopathogenic fungi. Further studies should be performed in order to better understand the mechanism of action of this and other antifungal compounds as well as safety issues.
Keywords: Antifungal activity, antifungal proteins, basidiomycetes, grifolin.
Current Topics in Medicinal Chemistry
Title:A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds
Volume: 13 Issue: 21
Author(s): Maria Jose Alves, Isabel C.F.R. Ferreira*, Joana Dias, Vania Teixeira, Anabela Martins and Manuela Pintado*
Affiliation:
- Centro de Investigação de Montanha (CIMO), ESA, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança,Portugal
- CBQF-Escola Superior de Biotecnologia, Universidade Católica Portuguesa Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto,Portugal
Keywords: Antifungal activity, antifungal proteins, basidiomycetes, grifolin.
Abstract: The present review reports the antifungal activity of mushroom extracts and isolated compounds including high (e.g. peptides and proteins) and low (e.g. sesquiterpenes and other terpenes, steroids, organic acids, acylcyclopentenediones and quinolines) molecular weight compounds. Most of the studies available on literature focused on screening of antifungal activity of mushroom extracts, rather than of isolated compounds. Data indicate that mushroom extracts are mainly tested against different Candida species, while mushroom compounds are mostly tested upon other fungi. Therefore, the potential of these compounds might be more useful in food industry than in clinics. Oudemansiella canarii and Agaricus bisporus methanolic extracts proved to be the most active mushroom extracts against Candida spp. Grifolin, isolated from Albatrellus dispansus, seemed to be the most active compound against phytopathogenic fungi. Further studies should be performed in order to better understand the mechanism of action of this and other antifungal compounds as well as safety issues.
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Cite this article as:
Alves Jose Maria, Ferreira C.F.R. Isabel*, Dias Joana, Teixeira Vania, Martins Anabela and Pintado Manuela*, A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds, Current Topics in Medicinal Chemistry 2013; 13 (21) . https://dx.doi.org/10.2174/15680266113136660191
DOI https://dx.doi.org/10.2174/15680266113136660191 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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