Synthesis, In Vitro Activity and Rationalisation of a Series of Dialkyl Esters of 5-Aminosulfonylisophthanoate as Potential Estrone Sulfatase (ES) Inhibitors
Chirag K. Patel.
We consider dialkyl esters of 5-aminosulfonylisophthanoate-based compounds in our efforts to determine factors
involved in determining the overall inhibitory activity against estrone sulfatase (ES). We propose that the weak inhibition
observed is due to the increased electron density in the area of the phenyl ring close to the sulfamate moiety.
Keywords: Estrone sulfatase, Irreversible, Inhibition, Breast cancer, Isophthanoic acid esters, Electron density, ES inhibitor.
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