Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge


Sudden Infant Death Following Hexavalent Vaccination: A Neuropathologic Study

Author(s): L. Matturri, G. Del Corno and A.M. Lavezzi

Affiliation: “Lino Rossi” Research Center, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy, Via della Commenda, 19 - 20122 Milan, Italy.


We examined a large number of sudden infant death syndrome victims in order to point out a possible causal relationship between a previous hexavalent vaccination and the sudden infant death. We selected 110 cases submitted to in-depth histological examination of the autonomic nervous system and provided with detailed clinical and environmental information. In 13 cases (11.8%) the death occurred in temporal association with administration of the hexavalent vaccine (from 1 to 7 days). In none of these victims congenital developmental alterations of the main nervous structures regulating the vital functions were observed. Only the hypoplasia of the arcuate nucleus was present in 5 cases. In one case in particular an acquired hyperacute encephalitis of the tractus solitarii nucleus was diagnosed in the brainstem. This study does not prove a causal relationship between the hexavalent vaccination and SIDS. However, we hypothesize that vaccine components could have a direct role in sparking off a lethal outcome in vulnerable babies. In conclusion, we sustain the need that deaths occurring in a short space of time after hexavalent vaccination are appropriately investigated and submitted to a post-mortem examination particularly of the autonomic nervous system by an expert pathologist to objectively evaluate the possible causative role of the vaccine in SIDS.

Keywords: Autonomic nervous system, brainstem, hexavalent vaccine, neuropathology, risk factors, SIDS.

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Article Details

Page: [941 - 946]
Pages: 6
DOI: 10.2174/09298673113206660289