Abstract
In the search for novel antiarrhythmic strategies, the cardiac Na+/Ca2+ exchanger (NCX) seems to be a promising target. Recent insights into the role of NCX in proarrhythmia stem from transgenic murine models with knockout or overexpression of NCX. There are significant differences regarding cellular electrophysiology, excitation-contraction coupling and Ca2+ handling when comparing mice to higher mammal and most importantly human physiology. We here review findings derived from transgenic mouse models regarding the role of NCX in the generation of arrhythmia and discuss principle aspects to consider when translating physiological and pathophysiological mechanisms from mouse models into human physiology and the clinical context.
Keywords: Transgenic mouse models, Na+/Ca2+ exchanger, translational research.
Current Medicinal Chemistry
Title:Advantages and Limitations of Transgenic Mice: The Role of the Na+/Ca2+ Exchanger in Cardiac Electrophysiology and Arrhythmia
Volume: 21 Issue: 11
Author(s): N. Bogeholz, L. Eckardt and C. Pott
Affiliation:
Keywords: Transgenic mouse models, Na+/Ca2+ exchanger, translational research.
Abstract: In the search for novel antiarrhythmic strategies, the cardiac Na+/Ca2+ exchanger (NCX) seems to be a promising target. Recent insights into the role of NCX in proarrhythmia stem from transgenic murine models with knockout or overexpression of NCX. There are significant differences regarding cellular electrophysiology, excitation-contraction coupling and Ca2+ handling when comparing mice to higher mammal and most importantly human physiology. We here review findings derived from transgenic mouse models regarding the role of NCX in the generation of arrhythmia and discuss principle aspects to consider when translating physiological and pathophysiological mechanisms from mouse models into human physiology and the clinical context.
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Bogeholz N., Eckardt L. and Pott C., Advantages and Limitations of Transgenic Mice: The Role of the Na+/Ca2+ Exchanger in Cardiac Electrophysiology and Arrhythmia, Current Medicinal Chemistry 2014; 21 (11) . https://dx.doi.org/10.2174/09298673113206660284
DOI https://dx.doi.org/10.2174/09298673113206660284 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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