Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
Email: lddd@benthamscience.org


Synthesis and in vivo Antihyperlipidemic Potential of Novel Substituted Thieno[3,2-d]pyrimidines

Author(s): Riyaj Shaukat Tamboli, Rakesh Devidas Amrutkar, Kishor Sanchlal Jain, Muthu Kumaradoss Kathiravan.


A novel series of substituted thieno[3,2-d]pyrimidin-4(3H)ones 7-22 has been synthesized and evaluated for in vivo antihyperlipidemic activity using Triton WR 1339. Out of the 16 compounds synthesized and tested, 8 compounds have shown significant effect on total lipid profile. These compounds are several times more potent than gemfibrozil, the standard drug used for comparison. The superior activity of compounds 16 and 19 may be because of their esterase mediated metabolism into active metabolites. These compounds may serve to be ideal leads to provide newer antihyperlipidemic agents.

Keywords: Antihyperlipidemic agents, Gemfibrozil, Lipid profile, Synthesis, Thieno[3, 2-d]pyrimidines, Vitamin B3.

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Article Details

Year: 2013
Page: [906 - 915]
Pages: 10
DOI: 10.2174/15701808113109990019
Price: $58