Abstract
A series of dihydropyridine analogous was synthesized and evaluated for anticonvulsant activity using PTZ animal model. The main strategies are introducing a non-classical dihydropyridine like structure as anti-seizure agent. Some compounds showed significant anticonvulsant activity in comparison with the control group.
Keywords: Seizure, Anticonvulsant, Hexahydroquinoline derivative, 1, 4-dihydropyrimidine derivative, PTZ animal model, Synthesis.
Letters in Drug Design & Discovery
Title:Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures
Volume: 10 Issue: 9
Author(s): Mohammad Sharifzadeh, Hamid Reza khademi, Ali Almasirad, Zahra rezayan, Mohsen Rezayan Ghayahbashi and Mohsen Amini
Affiliation:
Keywords: Seizure, Anticonvulsant, Hexahydroquinoline derivative, 1, 4-dihydropyrimidine derivative, PTZ animal model, Synthesis.
Abstract: A series of dihydropyridine analogous was synthesized and evaluated for anticonvulsant activity using PTZ animal model. The main strategies are introducing a non-classical dihydropyridine like structure as anti-seizure agent. Some compounds showed significant anticonvulsant activity in comparison with the control group.
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Cite this article as:
Sharifzadeh Mohammad, khademi Reza Hamid, Almasirad Ali, rezayan Zahra, Ghayahbashi Rezayan Mohsen and Amini Mohsen, Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures, Letters in Drug Design & Discovery 2013; 10 (9) . https://dx.doi.org/10.2174/15701808113109990015
DOI https://dx.doi.org/10.2174/15701808113109990015 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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