Synthesis and Anticonvulsant Activity of Some Non-Classical Dihydropyridine Like Structures

Author(s): Mohammad Sharifzadeh, Hamid Reza khademi, Ali Almasirad, Zahra rezayan, Mohsen Rezayan Ghayahbashi, Mohsen Amini.

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 9 , 2013

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Abstract:

A series of dihydropyridine analogous was synthesized and evaluated for anticonvulsant activity using PTZ animal model. The main strategies are introducing a non-classical dihydropyridine like structure as anti-seizure agent. Some compounds showed significant anticonvulsant activity in comparison with the control group.

Keywords: Seizure, Anticonvulsant, Hexahydroquinoline derivative, 1, 4-dihydropyrimidine derivative, PTZ animal model, Synthesis.

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Article Details

VOLUME: 10
ISSUE: 9
Year: 2013
Page: [900 - 905]
Pages: 6
DOI: 10.2174/15701808113109990015
Price: $58

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