Synthesis and Antiproliferative Activity of New Polyoxo 2-Benzyl-2,3- dihydrobenzofurans and Their Related Compounds
A set of new polyoxo 2-benzyl-2,3-dihydrobenzofurans and their related compounds, including 2-
benzylbenzofuran-3(2H)-ones and 2-benzylbenzofurans, were designed and synthesized. Their antiproliferative activities
were evaluated against human gastric cancer (SGC-7901), human fibrosarcoma (HT-1080) and human oral epidermoid
carcinoma (KB) cell lines in vitro. Preliminary results showed that some polyoxo 2-benzyl-2,3-dihydrobenzofurans and
their related compounds had significant activity comparable with that of cisplatin.
Keywords: Antiproliferative activity, Synthesis, Aurone, 2-Benzyl-2, 3-dihydrobenzofuran, 2-Benzylbenzofuran-3(2H)-ones,
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