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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities

Author(s): Ratchanok Pingaew, Apilak Worachartcheewan, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul

Volume 10, Issue 9, 2013

Page: [859 - 864] Pages: 6

DOI: 10.2174/15701808113109990004

Price: $65

Abstract

Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of 8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds.

Keywords: Metal complex, 8-aminoquinoline, Uracils, Antioxidant, Cytotoxicity.


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