Transition Metal Complexes of 8-Aminoquinoline-5-Substituted Uracils with Antioxidative and Cytotoxic Activities
Metal complexes of 8-aminoquinoline (8AQ) derivatives were reported. This study presents a series of synthesized
transition metal complexes of mixed ligands 8AQ-5-iodouracils (1-3) and 8AQ-5-nitrouracil (4-6) which have been
investigated for their antioxidative and cytotoxic activities, as well as, powder X-ray diffraction patterns. Ni complex of
8AQ-5-nitrouracil (6) exerted significant cytotoxicity against MOLT-3 cell and superoxide scavenging activity. The results
demonstrate an application of 8AQ molecule as a potential ligand for new bioactive compounds.
Keywords: Metal complex, 8-aminoquinoline, Uracils, Antioxidant, Cytotoxicity.
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