Tocopherols, with a phytyl side chain in its chroman ring, belong to vitamin E family and have several effects on organisms.
They are also classified as therapeutics against different types of human diseases. Especially important roles in cell signaling and gene
regulatory mechanisms make tocopherols crucial as therapeutic agents. Aging is accompanied with several degenerative disorders including
cardiovascular, neuronal and metabolic diseases. The role of free radical damage in aging has been identified and tocopherols were
shown to be involved in age related disorders. Recent studies and future directions will be focused in this review regarding the molecular
functions of tocopherols.
Keywords: Tocopherol, aging, atherosclerosis, Alzheimer’s disease, nonalcoholic fatty liver disease.
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