Current Genomics

Christian Néri
Institute of Biology Paris-Seine
CNRS UMR 8256 and UPMC
Paris, 75005


Actin-associated Proteins in the Pathogenesis of Podocyte Injury

Author(s): Fang-Fang He, Shan Chen, Hua Su, Xian-Fang Meng and Chun Zhang

Affiliation: Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.


Podocytes have a complex cellular architecture with interdigitating processes maintained by a precise organization of actin filaments. The actin-based foot processes of podocytes and the interposed slit diaphragm form the final barrier to proteinuria. The function of podocytes is largely based on the maintenance of the normal foot process structure with actin cytoskeleton. Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filtration barrier, and in the pathogenesis of glomerular diseases. In this review, we focused on recent findings on the mechanisms of organization and reorganization of these actin-related molecules in the pathogenesis of podocyte injury and potential therapeutics targeting the regulation of actin cytoskeleton in podocytopathies.

Keywords: Actin cytoskeleton, α-actinin-4, CD2-associated protein, Foot processes, Podocyte, Slit diaphragm.

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Article Details

Page: [477 - 484]
Pages: 8
DOI: 10.2174/13892029113146660014