Green Access to Multi-Component Synthesis of Spiropyranopyrazoles

Author(s): D. M. Pore, P. G. Hegade, D. S. Gaikwad, P. B. Patil, J. D. Patil.

Journal Name: Letters in Organic Chemistry

Volume 11 , Issue 2 , 2014

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A catalyst-free multi-component synthesis of spiro[indoline-3,4’-pyrano[2,3-c]pyrazoles] is reported from in situ formed pyrazolone by exothermic reaction of ethyl acetoacetate with hydrazine hydrate, isatin and malononitrile in water at room temperature. A suggested mechanistic approach was supported by semi-empirical calculations. The transformation is carried out in water alone and thus achieved the highest level of green chemistry. Simple reaction conditions, easy work-up procedure and isolation of products are the auxiliary advantages of present protocol.

Keywords: Spiroheterocycles, catalyst-free, pyranopyrazole, environmentally-friendly, water.

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Article Details

Year: 2014
Page: [131 - 135]
Pages: 5
DOI: 10.2174/15701786113106660069
Price: $65

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