Mucosal Vaccines: Where Do We Stand?

Author(s): Jean-Pierre Kraehenbuhl, Marian R. Neutra.

Journal Name: Current Topics in Medicinal Chemistry

Volume 13 , Issue 20 , 2013

Abstract:

Mucosal vaccinology is a relatively young but rapidly expanding discipline. At present the vast majority of vaccines are administered by injection, including vaccines that protect against mucosally acquired pathogens such as influenza virus and human papilloma virus. However, mucosal immune responses are most efficiently induced by the administration of vaccines onto mucosal surfaces. The small number of currently licensed mucosal vaccines have reduced the burden of disease and mortality caused by enteric pathogens including rotavirus, V. cholerae and S. typhi, or those that spread to affect distal organs such as poliovirus. Expanding knowledge about the special features of the mucosal immune system promises to accelerate development of mucosal vaccines that could contribute significantly to protection against pathogens that colonize or invade via mucosal surfaces including HIV, Shigella, ETEC, Campylobacter jejuni, Helicobacter pylori and many others.

Keywords: Epithelia, mucosae, vaccines, pathogens.

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Article Details

VOLUME: 13
ISSUE: 20
Year: 2013
Page: [2609 - 2628]
Pages: 20
DOI: 10.2174/15680266113136660186

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