Current Topics in Medicinal Chemistry

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA


Immune Senescence and Vaccination in the Elderly

Author(s): Pierre Olivier Lang, Sheila Govind, Annemieke ten Bokum, Natalie Kenny, Emmanuel Matas, David Pitts and Richard Aspinall

Affiliation: Nescens Centre of preventive medicine c/o Clinique of Genolier – Rue du Muids, 3 – CH-1272 Genolier, Switzerland.

Keywords: Healthy aging, immunosenescence, older adults, vaccination, vaccine design, vaccine development, vaccine effectiveness.


Vaccines are powerful public health tools that have been of tremendous benefit in protecting vulnerable populations worldwide from many pathogens. However, vaccine- preventable diseases still remain a considerable burden and this is particularly true among aging and aged populations in industrialized countries. The predicted demographic shift in the population landscape towards an ever-increasing aging population and the evidence suggesting that older individuals mount less-than optimal immune response to vaccination have raised the question of improving vaccine responses in older individuals. This review presents recent progress in the understanding at the cellular and molecular levels of age related immune decline and strategies to translate current knowledge into the development of immunization strategies to promote healthy aging, keeping older members of our society autonomous and independent.

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Article Details

Page: [2541 - 2550]
Pages: 10
DOI: 10.2174/15680266113136660181