Novel Strategies for Development of Next-Generation Glycoconjugate Vaccines
Fikri Y. Avci
Affiliation: Department of Biochemistry and Molecular Biology, Center for Molecular Medicine, University of Georgia, 315 Riverbend Rd. Athens, GA 30602, USA.
Most bacterial pathogens are decorated with surface glycans called capsular polysaccharides (CPSs). Each CPS
has a unique structure that is distinctively recognized by our immune cells. These polysaccharides are important vaccine
candidates given that they are located on the surface of pathogens, are easily accessible by the immune system, and often
result in formation of protective antibodies. To induce CPS specific adaptive immune response (i.e., T cell-mediated B
cell response), CPSs are conjugated with carrier proteins, and the conjugation products are called glycoconjugate vaccines.
Immunization with glycoconjugate vaccines has had significant health benefits in controlling infections caused by
Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis. However, owing to insufficient understanding
of their immune activation mechanisms, glycoconjugate vaccines have been designed and synthesized empirically.
In recent years, we have witnessed important advancements in the glycoconjugate vaccine field: the discovery of the
mechanism of action for glycoconjugate vaccines, a novel in vivo conjugation strategy, and progress in the use of novel
carriers. These studies will be reviewed in detail herein.
Keywords: Adaptive immunity, B cells, glycoconjugate vaccines, Immunoglobulin G, infectious diseases, polysaccharides,
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